Integrating Detoxification & Metabolic Fitness, & Mitochondrial Health | IAOMT – International Academy of Oral Medicine and Toxicology

Dr. Chris ShadeMay 14, 2026

Discussing the glutathione system’s role in detoxification and metabolic fitness, emphasizing its importance in chemo protection and antioxidant activity, Dr. Christopher Shade highlighted the impact of mercury on glutathione and the NRF2 pathway, which regulates genes for chemo protection. Shade explained the detoxification phases (1, 2, 3) and the importance of maintaining glutathione levels and enzyme activities. He also covered the role of phytochemicals, sulfur compounds, and lipoic acid in upregulating NRF2 and glutathione, and the use of intestinal binders and phosphatidylcholine for detoxification. The discussion included the impact of inflammation and age on detoxification and the need for targeted supplementation and therapies.

IN THIS EPISODE:
10:35 Mitochondria and Immunity
13:22 Antioxidant – Detoxification – Proteins
48:36 NAD+ Balance with Methylation
50:10 Post Covid Sydrome
51:01 Mechanism Considerations

Dr. Shade’s Protocols

Weekly deep dives into real health problems, decoded through chemistry and systems biology. Each issue breaks down the catalyst, the mechanism, and the protocol that actually works.